alexa Effects of antidepressants and benzodiazepines on stimulated salivary flow rate and biochemistry composition of the saliva.


Biochemistry & Physiology: Open Access

Author(s): de Almeida Pdel V, Grgio AM, Brancher JA, Igncio SA, Machado MA,

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Abstract OBJECTIVES: To evaluate the effect of psychotropics on stimulated salivary flow rate (SSFR), total proteins, urea and calcium concentration, alpha-amylase activity, pH, saliva buffer capacity (SBC), and the prevalence of xerostomia in psychotropic users and its relationship with low SSFR and/or hyposalivation. STUDY DESIGN: Thirty-three subjects were allocated to 4 groups: I (control): II (psychotropic users); III (subjects of group II using only selective serotonin reuptake inhibitors [SSRIs]); and IV (subjects of group II using SSRIs at recommended initial dose). The SBC was obtained by titrimetry and salivary composition by colorimetric method. RESULTS: Group II presented a significant decrease (P = .0203), of 33.85\% in SSFR compared with group I. Mean SSFR values in groups III and IV showed no significant difference compared with control group (P > .05). Xerostomia was observed in 37.50\%, 38.46\%, and 50\% of subjects in groups II, III, and IV, respectively. Biochemical composition, pH, and SBC were not significantly affected (P > .05) by the use of psychotropics. CONCLUSIONS: Xerostomia was associated with a decrease in SSFR and not with alterations in biochemical composition. Even when using the latest-generation drugs, there were complaints of xerostomia associated with decrease in SSFR. This article was published in Oral Surg Oral Med Oral Pathol Oral Radiol Endod and referenced in Biochemistry & Physiology: Open Access

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