alexa Effects of calcium channel antagonists on the reinforcing properties of morphine, ethanol and cocaine as measured by place conditioning.
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Alcoholism & Drug Dependence

Author(s): Biaa G, Langwiski R, Biaa G, Langwiski R, Biaa G, Langwiski R, Biaa G, Langwiski R

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Abstract Morphine, ethanol and cocaine were examined in place conditioning paradigm. After initial preferences were determined, animals were conditioned with morphine (5 mg/kg), ethanol (1 g/kg) and cocaine (5 mg/kg) alone or combinations of these drugs plus some calcium antagonists: nifedipine (5 and 10 mg/kg) and verapamil (5 and 10 mg/kg). Nifedipine prevented the ability of morphine and cocaine, but not of ethanol, to produce a place preference. Our results suggest that substances which can influence calcium distribution are involved in the rewarding actions of some drugs-morphine and cocaine. Dihydropyridine, a calcium channel antagonists might be clinically useful for the treatment of morphine and cocaine abuse.
This article was published in J Physiol Pharmacol and referenced in Journal of Alcoholism & Drug Dependence

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