Author(s): Lu JX, Prudhommeaux F, Meunier A, Sedel L, Guillemin G
Abstract Share this page
Abstract The aim of this work is to study the effects of chitosan on rat knee cartilages. 0.2 ml of 0.1\% chitosan solution pH = 6.9 were injected inside rat knees articular cavity. One, three and six weeks after injection, histological and histomorphometric studies were performed on undecalcified samples embedded in polymethylmetacrylate. Results show that after 1 and 6 weeks: (i) chitosan slows significantly (P < 0.005) the decrease in epiphyseal cartilage thicknesses and (ii) increases significantly articular cartilage chondrocyte densities (P < 0.002). However chitosan solution induces a proliferation of fibrous tissue with abundant fibroblasts, fibrocytes and monocytes inside the joint and this proliferation is still present after 6 weeks. This study suggests that chitosan could act on the growth of epiphyseal cartilage and wound healing of articular cartilage.
This article was published in Biomaterials
and referenced in Journal of Molecular and Genetic Medicine