Author(s): Dent JG, Netter KJ, Gibson JE
Abstract Share this page
Abstract Parameters relating to hepatic microsomal drug metabolism were measured in vitro following 2 weeks exposure of rats to polybrominated biphenyls (PBB) as a dietary supplement at 4.69, 18.75, 75 and 300 ppm. The mixture of PBB was a potent inducer of hepatic microsomal drug metabolism. The pattern of induction seen after PBB exposure was compared with that produced by phenobarbital and 3-methyl-cholanthrene and the pattern of induction observed shared similarities with both of these agents.
This article was published in Res Commun Chem Pathol Pharmacol
and referenced in Journal of Clinical Toxicology