alexa Effects of peripheral nerve injury on functional spinal VR1 receptors.
Medicine

Medicine

Alternative & Integrative Medicine

Author(s): Kelly S, Chapman V

Abstract Share this page

Abstract VR1 receptors, present on Adelta- and C-fibres and post-synaptic sites within the spinal cord dorsal horn, is an integrator of noxious stimuli. Here, the contribution of spinal VR1 receptors to spinal nociceptive processing in nerve injured (selective spinal nerve ligated SNL) and sham anaesthetised rats was studied. Spinal capsazepine (0.5-30 microM), a competitive VR1 antagonist, reduced noxious evoked responses of spinal neurones to a greater extent in sham operated rats, compared to SNL rats. Significant differences between the effect of spinal capsazepine on the non-potentiated component of the C-fibre evoked response of SNL and sham operated rats are reported (p< 0.01, two-way ANOVA). Our data suggest there is a functional plasticity of the spinal VR1 receptor following nerve injury.
This article was published in Neuroreport and referenced in Alternative & Integrative Medicine

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords