alexa Effects of steady electric fields on human retinal pigment epithelial cell orientation and migration in culture.
General Science

General Science

Biological Systems: Open Access

Author(s): Sulik GL, Soong HK, Chang PC, Parkinson WC, Elner SG, , Sulik GL, Soong HK, Chang PC, Parkinson WC, Elner SG,

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Abstract Low-level, steady electric fields of 6-10 volts/cm stimulated directional orientation and translocation of cultured human retinal pigment epithelial cells. The orientative movements (galvanotropism) consisted of somatic elongation of the cells into spindle shapes, followed by pivotal alignment orthogonal to the field. The anodal edges of the cells underwent retraction of their plasmalemmal extensions, while the cathode edges and the longitudinal ends developed lamellipodia and ruffled membranes. These tropic movements were followed by a translocational movement (galvanotaxis) of the cells towards the cathode. Staining of these migrating cells for actin showed the accumulation of stress fibers at the leading (cathodal) edge, as well as at the longitudinal ends of the elongated somata. These results suggest that endogenous, biologically-generated electric fields (eg., injury currents) may play a role in the guidance and migration of retinal pigment epithelial cells after retinal injury.
This article was published in Acta Ophthalmol (Copenh) and referenced in Biological Systems: Open Access

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