alexa Effects of two basidiomycete species on interleukin 1 and interleukin 2 production by macrophage and T cell lines.


Journal of Integrative Oncology

Author(s): Kawanishi T, IkedaDantsuji Y, Nagayama A, Kawanishi T, IkedaDantsuji Y, Nagayama A, Kawanishi T, IkedaDantsuji Y, Nagayama A, Kawanishi T, IkedaDantsuji Y, Nagayama A

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Abstract Two basidiomycete species, Lentinus edodes mycelia (LEM) and Cordyceps sinensis (CS) were examined for induction of cytokines in murine macrophage cell line R309 (R309) and T cell line LBRM-33 1A5 (1A5). When lipopolysaccharide (LPS)-activated R309 were exposed to the extracts of basidiomycetes, R309 induced significant levels of interleukin 1 (IL-1). Interleukin 2 (IL-2) induction was recognized in 1A5 cultures in the presence of IL-1 and phytohemagglutinin (PHA). However, no enhancement of IL-2 production by these basidiomycetes was discerned in 1A5 cultures with IL-1 and PHA, i.e., direct action of basidiomycetes was not found on IL-2 production of 1A5. PHA-stimulated 1A5 exposed to basidiomycetes induced IL-2 without IL-1 when co-cultured with LPS-activated R309 as a source of IL-1. Effects of basidiomycetes on IL-2 production in 1A5 seemed to be caused through their action on macrophages. The induction of IL-2, Th1 type cytokine in T lymphocyte, is a significant finding since basidiomycetes, taken as a dietary supplement for immuno-suppressed patients, especially cancer patients, would be helpful in improving their immune activity against cancer. Copyright 2009 Elsevier GmbH. All rights reserved. This article was published in Immunobiology and referenced in Journal of Integrative Oncology

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