Author(s): Ueda F, Nagata M, Nagata T, Shimazaki Y
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Abstract 1. The effects of zinc (Zn2+) and ethylenediaminetetra-acetic acid (EDTA) on tissue cadmium (Cd2+) were investigated in the smooth muscles of rabbit trachea, taenia coli, aorta and guinea-pig taenia coli. 2. After an Cd uptake in high-K2+ solution, samples were rinsed with cold high-K2+, cold Zn2+ or cold EDTA solution without Cd2+ and the results were quantitatively different from each other. 3. Concentration-response curves were obtained with each treatment of cold solution. 4. It is suggested that tissue Cd2+ can be divided into 3 fractions in the surface membrane and there is another fraction in cellular space.
This article was published in Gen Pharmacol
and referenced in Journal of Environmental & Analytical Toxicology