Author(s): Nash T, Rice WG
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Abstract Twenty-nine of 34 (85\%) Zn-finger-active compounds at 300 microM or less inhibited the growth of Giardia lamblia. The most active compound, disulfiram (Antabuse), was cidal at 1.23 +/- 0.32 microM. In the adult mouse model, significant in vivo activity was demonstrated by increased cure rates and decreased parasite burdens.
This article was published in Antimicrob Agents Chemother
and referenced in Journal of Analytical & Bioanalytical Techniques