alexa Efficacy and safety of add-on levetiracetam in refractory childhood epilepsy.
Pediatrics

Pediatrics

Pediatrics & Therapeutics

Author(s): Kanemura H, Sano F, Tando T, Sugita K, Aihara M

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Abstract PURPOSE: The purpose of the present study was to evaluate the efficacy and safety of levetiracetam (LEV) in refractory epileptic children. METHODS: The study group included 61 outpatients (7 generalized, 48 localization-related, 3 undetermined, 3 unclassified) aged between 16 months and 18 years. LEV was given twice daily at a total dose of 10 mg/kg/day. The final mean dose was 50.7 mg/kg/day. The mean number of prior anti-epileptic drugs was 5.2. The entire treatment period was more than 6 months after LEV administration. RESULTS: Fifteen children (24.6\%) became seizure-free for 6 months after starting LEV, and 18 (29.5\%) had a seizure reduction of more than 50\% for the entire 6 months. The response rate was 33/61 (54.1\%). Responders included 2/3 of patients (66.7\%) with epilepsy with continuous spikes and waves during slow sleep and 13/19 (68.4\%) with frontal lobe epilepsy. The effective dosage of LEV in the responders demonstrated a wide range (mean, 46.1 mg/kg/day; range, 19.4-59.1 mg/kg/day), and showed bimodal distribution. Adverse events occurred in only two patients who did not require LEV discontinuation. CONCLUSION: LEV represents an important addition to the treatments available for refractory epileptic children. Copyright © 2012 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved. This article was published in Brain Dev and referenced in Pediatrics & Therapeutics

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