Author(s): Indap MA, Indap MA, Ambaye RY, Ambaye RY, Indap MA, Ambaye RY, Indap MA, Ambaye RY
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Abstract Combination chemotherapy studies were carried out in vivo against sarcoma 180 (ascites)(S180) and Ehrlich (ascites) carcinoma (EAC) tumours using cytotoxic drugs and methoxyphenyl maleamic acid (MPMA), an intermediate in the synthesis of pyrrolidine-nitrogen-mustards. Preliminary data have suggested that the combination of 5-fluorouracil (5-FU) and methoxyphenyl maleamic acid (MPMA) was more active than 5-FU used singly against EAC tumour. The possible therapeutic potential of this combination was further investigated in EAC tumour.
This article was published in J Postgrad Med
and referenced in Journal of Chemical Engineering & Process Technology