alexa Efficacy of intermittent preventive treatment with sulfadoxine-pyrimethamine on placental parasitemia in pregnant women in midwestern Nigeria.


Journal of Addiction Research & Therapy

Author(s): Aziken ME, Akubuo KK, Gharoro EP

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Abstract OBJECTIVE: To assess the effect of intermittent preventive treatment with sulfadoxine and pyrimethamine (IPT-SP) on placental parasitemia and maternal and perinatal outcome. METHODS: We compared placental malaria parasitemia during pregnancy and pregnancy outcome in 2 groups of women receiving antenatal care at University of Benin Teaching Hospital. One group was prophylactically treated with IPT-SP and the other was not treated. RESULTS: The parasitemia rates for peripheral, placental, and cord blood were 11.9\%, 11.4\%, and 2.7\% in the IPT-SP group (n=370) and 19.1\%, 22.6\%, and 6.2\% in the control group (n=371) (P=0.006, P=0.002, and P=0.02, respectively). The treatment reduced the odds of placental parasitemia by 37\% (OR 0.63; 95\% CI, 0.48-0.81). Peripheral (P=0.002) and placental (P=0.001) parasitemia were significantly reduced in the subgroup of women who took 2 or 3 doses of SP. Fewer women (16.2\%) in the IPT-SP group than the control group (23.7\%) had symptomatic malaria. Anemia at delivery was significantly lower in the IPT-SP group (10.8 vs 1.6\%). The risks of abortion, preterm delivery, and low birth weight were also significantly lower in the IPT-SP group. CONCLUSION: IPT-SP is effective in preventing placental parasitemia, and reduces rates of malaria, maternal anemia, abortion, preterm delivery and low birth weight among pregnant women. Copyright © 2010 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved. This article was published in Int J Gynaecol Obstet and referenced in Journal of Addiction Research & Therapy

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