alexa Efficacy of tocilizumab in refractory giant cell arteritis.


Journal of Arthritis

Author(s): Vinit J, Bielefeld P, Muller G, Besancenot JF

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Abstract Giant cell arteritis is the most frequent form of vasculitis characterized by a high risk of vascular thrombosis. Major complications are blindness and other vascular ischemia but bowel ischemic involvement is rare. Treatment is based on long-term steroid therapy with numerous side effects. The efficacy of immunosuppressive drugs like azathioprine methotrexate or anti-tumor necrosis factor antibodies appears to be too low to reduce the use of steroids. Th17 lymphocytes and interleukin-6 play an important role in pathogenesis of giant cell arteritis. We report here a case of effective interleukin-6 blocker in the treatment of refractory giant cell arteritis with ileitis and high-dose steroid dependence despite 2 years of treatment with steroids and methotrexate. After infusions of tocilizumab, no relapse at 6 months was found despite the decrease in corticosteroids. Copyright © 2011 Société française de rhumatologie. Published by Elsevier SAS. All rights reserved. This article was published in Joint Bone Spine and referenced in Journal of Arthritis

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