alexa Efficient reactivation of latent herpes simplex virus from mouse central nervous system tissues
Infectious Diseases

Infectious Diseases

Journal of Infectious Diseases & Therapy

Author(s): ShihHeng Chen, HuiWen Yao, WenYen Huang, KueiSen Hsu, HuanYao Lei

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For decades, numerous ex vivo studies have documented that latent herpes simplex virus (HSV) reactivates efficiently from ganglia, but rarely from the central nervous systems (CNS), of mice when assayed by mincing tissues before explant culture, despite the presence of viral genomes in both sites. Here we show that 88% of mouse brain stems reactivated latent virus when they were dissociated into cell suspensions before ex vivo explant culture. The efficient reactivation of HSV from the mouse CNS was demonstrated with more than one viral strain, viral serotype, and mouse strain, further indicating that the CNS can be an authentic latency site for HSV with the potential to cause recurrent disease.

This article was published in Journal of Virology and referenced in Journal of Infectious Diseases & Therapy

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