alexa Ehlers-Danlos syndrome and multiple sclerosis: a possible association.


Journal of Multiple Sclerosis

Author(s): Vilisaar J, Harikrishnan S, Suri M, Constantinescu CS

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Abstract Ehlers-Danlos syndrome (EDS) has various neurological manifestations. Here we present an association of EDS with multiple sclerosis (MS). Four MS patients from a total of 1892 followed up at our MS outpatient clinics had EDS. This frequency suggests 10-11 times increased prevalence of EDS in MS patients compared with the general population (P = 0.02). Suggested implications include a possible causal relationship on a connective tissue level with a higher susceptibility to MS in EDS. Diagnostic and management considerations are important in coexisting MS and EDS. Our patients had relatively florid lesions on brain MRIs and typical course and features of MS. This article was published in Mult Scler and referenced in Journal of Multiple Sclerosis

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