Author(s): Abu Zuhri AZ, AlKhalil S, Shubietah RM, ElHroub I
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Abstract The electrochemical reduction of tinidazole has been carried out in aqueous solution in the pH range 1.8-11.3 by differential-pulse (DP) polarography. Tinidazole exhibits one or two reduction peaks depending on pH. In strongly acidic solution (pH < 4.5), one reduction peak was obtained and it was suitable for analytical purposes. A method for the determination of tinidazole by DP polarography in Britton-Robinson buffer of pH 3.0, which allows quantification over the range 0.03-7.30 microg/ml, was proposed. The method was successfully applied to the determination of tinidazole in tablets with mean recovery and relative standard deviation of 98.7 and 3\%, respectively. Excipients did not interfere in the determination.
This article was published in J Pharm Biomed Anal
and referenced in Journal of Chromatography & Separation Techniques