alexa Elementary flux modes in a nutshell: properties, calculation and applications.
Bioinformatics & Systems Biology

Bioinformatics & Systems Biology

Metabolomics:Open Access

Author(s): Zanghellini J, Ruckerbauer DE, Hanscho M, Jungreuthmayer C

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Abstract Elementary flux mode (EFM) analysis allows the unbiased decomposition of a metabolic network into minimal functional units, making it a powerful tool for metabolic engineering. While the use of EFM analysis (EFMA) is still limited by the size of the models it can handle, EFMA has been successfully applied to solve real-world metabolic engineering problems. Here we provide a user-oriented introduction to EFMA, provide examples of recent applications, analyze current research strategies to overcome the computational restrictions and give an overview over current approaches, which aim to identify and calculate only biologically relevant EFMs. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This article was published in Biotechnol J and referenced in Metabolomics:Open Access

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