Author(s): RodriguezMorn M, GuerreroRomero F
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Abstract The aim of this study was to determine the relationship between serum magnesium and TNF-alpha levels in obese subjects. A cross-sectional population based study that included 192 non-diabetic, non-hypertensive subjects allocated in three categories of body mass index (BMI) <25; > or =25 to <30 kg/m2; and > or =30 kg/m2. Elevation of TNF-alpha levels was defined by serum levels > or =3.5 pg/mL, and low serum magnesium by levels < or = 0.74 mmol/L. Multivariate odds ratios (OR) adjusted by age, HOMA-IR index, and glucose tolerance status are presented. Obese subjects exhibited higher serum concentration of TNF-alpha (p = 0.002) and lower serum magnesium levels (p < 0.0001) than lean and overweight subjects. Ninety-one (47.4\%) subjects showed elevated levels of TNF-alpha, of them 7 (10.9\%), 31 (48.4\%), and 43 (67.2\%) in the groups with BMI <25, > or = 25 to < 0, and >> or =0 kg/m2, respectively. Multivariate OR between low serum magnesium and TNF-alpha levels in obese subjects was of 1.8, Cl95\% 1.2-9.1, P = 0.001, whereas in the lean and overweight individuals of 1.1, Cl95\% 0.7-8.7, P = 0.12, and 1.3, Cl95\% 0.9-10.8, P = 0.09, respectively. These data shows that low serum magnesium levels and elevated TNF-alpha are related in the obese subjects. It will be necessary to conduct more studies in order to add new data on this issue.
This article was published in Magnes Res
and referenced in Journal of Sports Medicine & Doping Studies