alexa Elimination of human leukemia cells in NOD SCID mice by WT1-TCR gene-transduced human T cells.
Microbiology

Microbiology

Journal of Antivirals & Antiretrovirals

Author(s): Xue SA, Gao L, Hart D, Gillmore R, Qasim W,

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Abstract Cytotoxic T lymphocytes (CTLs) specific for an HLA-A2-presented peptide epitope of the Wilms tumor antigen-1 (WT1) can selectively kill immature human leukemia progenitor and stem cells in vitro. In this study we have used retroviral gene transfer to introduce a WT1-specific T-cell receptor (TCR) into T lymphocytes obtained from patients with leukemia and from healthy donors. TCR-transduced T cells kill leukemia cells in vitro and display WT1-specific cytokine production. Intravenous injection of TCR-transduced T cells into nonobese diabetic-severe combined immunodeficiency (NOD/SCID) mice harboring human leukemia cells resulted in leukemia elimination, whereas transfer of control T cells transduced with an irrelevant TCR was ineffective. The data suggest that adoptive immunotherapy with WT1-TCR gene-modified patient T cells should be considered for the treatment of leukemia. This article was published in Blood and referenced in Journal of Antivirals & Antiretrovirals

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