Author(s): Salwiczek M, Qu Y, Gardiner J, Strugnell RA, Lithgow T,
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Abstract In order to colonize abiotic surfaces, bacteria and fungi undergo a profound change in their biology to form biofilms: communities of microbes embedded into a matrix of secreted macromolecules. Despite strict hygiene standards, biofilm-related infections associated with implantable devices remain a common complication in the clinic. Here, the application of highly dosed antibiotics is problematic in that the biofilm (i) provides a protective environment for microbes to evade antibiotics and/or (ii) can provide selective pressure for the evolution of antibiotic-resistant microbes. However, recent research suggests that effective prevention of biofilm formation may be achieved by multifunctional surface coatings that provide both non-adhesive and antimicrobial properties imparted by antimicrobial peptides. Such coatings are the subject of this review. Crown Copyright © 2013. Published by Elsevier Ltd. All rights reserved.
This article was published in Trends Biotechnol
and referenced in Journal of Analytical & Bioanalytical Techniques