alexa Empirical risk for insulin-dependent diabetes (IDD) in sibs. Further definition of genetic heterogeneity.
Immunology

Immunology

Journal of Clinical & Cellular Immunology

Author(s): Chern MM, Anderson VE, Barbosa J

Abstract Share this page

Abstract We have studied the effect of age at diagnosis in the proband and parental status [normal versus non-insulin-dependent diabetes (NIDD)] on the cumulative risk to age 40 (CR40) for insulin-dependent diabetes (IDD) in sibs of IDD probands in 493 families. We found a significantly increased cumulative risk to age 40 fro IDD in sibs of probands with disease diagnosed before age 10 (8.5 +/- 2.0\%) as compared with that in sibs of probands with disease diagnosed after age 10 (4.6 +/- 0.8\%) (X2 = 7.6, P = 0.006). Within the family subset with probands of earlier IDD onset (before age 10) we also found an increased CR40 for IDD in the sibs of the probands in families with an NIDD parent (with NIDD parent: CR40 = 7..5 +/- 2.0\%, X2 = 12.8, P less than 0.0005). These data are compatible with the theory of heterogeneity (genetic and/or environmental) of IDD and a possible relationship between IDD and NIDD.
This article was published in Diabetes and referenced in Journal of Clinical & Cellular Immunology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords