alexa Enantioselective induction of SIRT1 gene by syringaresinol from Panax ginseng berry and Acanthopanax senticosus Harms stem.
Chemistry

Chemistry

Natural Products Chemistry & Research

Author(s): Park HW, Cho SY, Kim HH, Yun BS, Kim JU,

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Abstract Syringaresinol exists either exclusively as one enantiomer or enantiomeric mixtures in plant foods. We found that (+)-syringaresinol, but not (-)-syringaresinol, upregulates silent information regulator two ortholog 1 (SIRT1) gene expression, and thus, Panax ginseng berry with predominantly high contents of (+)-syringaresinol exhibits higher activity in inducing SIRT1 gene expression than Acanthopanax senticosus Harms stem with almost equal proportion of the two enantiomers. These findings highlight the importance of the absolute configuration of syringaresinol for the biological activity. Copyright © 2014 Elsevier Ltd. All rights reserved. This article was published in Bioorg Med Chem Lett and referenced in Natural Products Chemistry & Research

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