Author(s): van den Oever IA, Raterman HG, Nurmohamed MT, Simsek S
Abstract Share this page
Abstract Endothelial dysfunction is regarded as an important factor in the pathogenesis of vascular disease in obesity-related type 2 diabetes. The imbalance in repair and injury (hyperglycemia, hypertension, dyslipidemia) results in microvascular changes, including apoptosis of microvascular cells, ultimately leading to diabetes related complications. This review summarizes the mechanisms by which the interplay between endothelial dysfunction, inflammation, and apoptosis may cause (micro)vascular damage in patients with diabetes mellitus.
This article was published in Mediators Inflamm
and referenced in Journal of Vascular Medicine & Surgery