alexa Enhanced in-vitro blood compatibility of 316L stainless steel surfaces by reactive landing of hyaluronan ions.
Pharmaceutical Sciences

Pharmaceutical Sciences

Pharmaceutical Regulatory Affairs: Open Access

Author(s): Voln M, Elam WT, Ratner BD, Turecek F, Voln M, Elam WT, Ratner BD, Turecek F

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Abstract A novel dry process for immobilization of hyaluronan on stainless steel surfaces is presented. This process that we call reactive landing is based on an interaction of hyperthermal gas-phase hyaluronan ions with plasma-cleaned and activated stainless steel surfaces. Reactive landing is performed on a unique instrument that combines an in-situ plasma reactor with an electrospray ion source and ion transfer optics. Gas-phase hyaluronan anions are obtained by electrospray ionization of sodium hyaluronan solutions and immobilized by reactive landing on large-area stainless steel surfaces. The immobilized hyaluronan withstands extensive washing with polar solvents and solutions, and the washed surfaces maintain the protective properties against blood platelet activation. The mechanism of hyaluronan discharge and immobilization is discussed. (c) 2006 Wiley Periodicals, Inc. This article was published in J Biomed Mater Res B Appl Biomater and referenced in Pharmaceutical Regulatory Affairs: Open Access

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