alexa Enhanced weight loss with protein-enriched meal replacements in subjects with the metabolic syndrome.
Diabetes & Endocrinology

Diabetes & Endocrinology

Journal of Obesity & Weight Loss Therapy

Author(s): FlechtnerMors M, Boehm BO, Wittmann R, Thoma U, Ditschuneit HH

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Abstract BACKGROUND: The objective of this study was to investigate the effects of a protein-rich diet in comparison with a conventional protein diet on weight loss, weight maintenance, and body composition in subjects with the metabolic syndrome. METHODS: Obese subjects received instructions for an energy-restricted diet with a calorie deficit of 500 kcal/day and were randomly assigned to either high-protein (1.34 g/kg body weight) or conventional protein (0.8 g/kg body weight) diets for 12 months. Protein-enriched meal replacements were used to enrich one arm of the diet with protein throughout the study. In all, 67\% of the participants completed the 1-year study. RESULTS: Subjects following the high-protein diet lost more body weight and more fat mass compared with those on the conventional protein diet, whereas the loss of fat-free mass was similar in both diet groups. Biochemical parameters associated with the metabolic syndrome improved in both diet groups. Improvements were modestly greater in subjects with the high-protein diet. After 12 months of treatment, 64.5\% of the subjects in the high-protein diet group and 34.8\% of the subjects in the conventional diet group no longer met three or more of the criteria for having the metabolic syndrome. CONCLUSIONS: Individuals with the metabolic syndrome achieved significant weight loss while preserving fat-free mass when treated with an energy-restricted, high-protein diet that included nutrient-dense meal replacements, as compared with the results for conventional protein intake. An intervention with a protein-enriched diet may have advantages for the management of the metabolic syndrome. Copyright (c) 2010 John Wiley & Sons, Ltd. This article was published in Diabetes Metab Res Rev and referenced in Journal of Obesity & Weight Loss Therapy

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