Author(s): Staros JV, Wright RW, Swingle DM
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Abstract Water-soluble carbodiimides are frequently employed in coupling or conjugation reactions, e.g., to link a peptide immunogen to a carrier protein. However, their utility is limited by low coupling yields obtained under some conditions. We have found that addition of N-hydroxysulfosuccinimide to such reactions can greatly enhance the yields obtained.
This article was published in Anal Biochem
and referenced in Pharmaceutica Analytica Acta