alexa Enterovirus 71 meningoencephalitis complicating rituximab therapy.


Journal of Antivirals & Antiretrovirals

Author(s): Ahmed R, Buckland M, Davies L, Halmagyi GM, Rogers SL,

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Abstract We describe a fatal case of proven enterovirus 71 meningoencephalitis complicating monoclonal anti-CD20 antibody therapy for non-Hodgkin's lymphoma. B-cell depletion, an effective treatment strategy in an expanding spectrum of hematological and inflammatory disorders, impairs neutralising antibody-mediated clearance of enterovirus. The global threat of emerging neurotropic viruses such as enterovirus 71 is heightened by an increasing pool of susceptible individuals in non-endemic regions. Copyright © 2011 Elsevier B.V. All rights reserved. This article was published in J Neurol Sci and referenced in Journal of Antivirals & Antiretrovirals

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