alexa ent-Kaur-16-en-19-oic acid, a KB cells cytotoxic diterpenoid from Elaeoselinum foetidum.
Chemical Engineering

Chemical Engineering

Journal of Bioprocessing & Biotechniques

Author(s): Mongelli E, Pomilio AB, Snchez JB, Guerra FM, Massanet GM, Mongelli E, Pomilio AB, Snchez JB, Guerra FM, Massanet GM

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Abstract Toxic and cytotoxic activities of the toxic plant Elaeoselinum foetidum (Apiaceae) were evaluated using the brine shrimp toxicity (BST) and KB cell cytotoxicity assays. The active chloroform extract was subjected to a bioactivity-directed fractionation, monitored by the BST assay, that led to the isolation of the diterpenoid ent-kaur-16-en-19-oic acid. This compound was potent against the brine shrimp (LC(50) = 4.8 microg/mL) and KB cells (IC(50) = 1.6 microg/mL). Copyright 2002 John Wiley & Sons, Ltd. This article was published in Phytother Res and referenced in Journal of Bioprocessing & Biotechniques

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