alexa Enzymatic versus autolytic debridement of chronic leg ulcers: a prospective randomised trial.
Physicaltherapy & Rehabilitation

Physicaltherapy & Rehabilitation

Journal of Novel Physiotherapies

Author(s): Knig M, Vanscheidt W, Augustin M, Kapp H

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Abstract OBJECTIVE: A randomised clinical trial (n = 42) compared the effectiveness of two approaches to debriding chronic leg ulcers: TenderWet 24, which is designed to support the autolytic degradation process, and Iruxol N (Santyl), an enzymatic treatment claimed to enhance the degradation process. METHOD: Patients were randomly assigned to one of the two treatment groups for three weeks. Wounds were evaluated weekly for the amount of eschar/slough, the area of healthy granulation and the re-epithelialised area. RESULTS: During days 1-14 slough within the groups was reduced by almost 19\% for TenderWet 24 and by 9\% for Iruxol N, followed by an increase of 26\% and 10\% respectively in granulation tissue. These effects were less accentuated during days 7-21. There was a further 11\% improvement in tissue debridement for the TenderWet 24 group and a relapse (+9.1\%) in the Iruxol N group. CONCLUSION: Although TenderWet 24 appeared to be more efficient in a few cases, the general efficacy of the two products appeared to be almost the same as no statistically significant superiority of either product was found. This article was published in J Wound Care and referenced in Journal of Novel Physiotherapies

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