alexa Epidemiological characteristics and laboratory diagnosis of fungal keratitis. A three-year study.


Journal of Clinical & Experimental Ophthalmology

Author(s): Bharathi MJ, Ramakrishnan R, Vasu S, Meenakshi R, Palaniappan R

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Abstract PURPOSE: To study the epidemiological characteristics and laboratory diagnosis of fungal keratitis seen at a tertiary eye care referral centre in South India. METHODS: A retrospective review of all culture-proven fungal keratitis seen over a 3-year period, September 1999 through August 2002. RESULTS: Fungal aetiology were confirmed in 1095 (34.4\%) of 3183 corneal ulcers. The predominant fungal species isolated was Fusarium spp (471; 42.82\%) followed by Aspergillus spp (286; 26\%). Males (712; 65.08\%) were more often affected (P<0.0001). A large proportion of the patients (732; 66.85\%) were in the younger age group (21 to 50 years). A majority (879; 80.27\%) came from rural areas (P<0.0001), and most patients (709; 64.75\%) were farmers (P<0.0001). Ocular trauma (1009; 92.15\%) was a highly significant risk factor (P<0.0001) and vegetative injuries (671; 61.28\%) were identified as a significant cause for fungal keratitis (P<0.0001). 172 (15.71\%) patients had concurrent diabetes mellitus. The sensitivity of 10\% potassium hydroxide (KOH) wet mount preparation was higher (99.23\%) than Gram-stained smear (88.73\%) (P<0.0001). Incidence of fungal keratitis was higher between June and September. CONCLUSION: Agricultural activity and related ocular trauma were principal causes of mycotic keratitis. A potassium hydroxide (KOH) wet mount preparation is a simple, and sensitive, method for diagnosis
This article was published in Indian J Ophthalmol and referenced in Journal of Clinical & Experimental Ophthalmology

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