alexa Epidemiology and sensitivity of 8625 ICU and hematology oncology bacterial isolates in Europe. International Study Group.
Biochemistry

Biochemistry

Clinical & Medical Biochemistry

Author(s): Verbist L

Abstract Share this page

Abstract A multicenter in-vitro study was conducted in 13 countries between May and November, 1992 to determine both the current bacterial epidemiology in Intensive Care and Hematology/Oncology units and the susceptibility of the organisms to cefpirome and other commonly used antibacterials. Eighty-nine hospitals each collected 100 consecutive nonduplicate aerobic clinical isolates from patients in either an Intensive Care (81\%) or Hematology/Oncology (19\%) unit. The major sources of isolates were respiratory, skin/wound, blood and urine. The MIC of eight different antibiotics was determined using a custom microdilution plate. Predominant bacteria accounting for 80\% of the 8625 isolates included: staphylococci (26\%); Escherichia coli (17\%); Pseudomonas aeruginosa (12\%); Klebsiella spp. (10\%); Enterobacter spp. (8\%) and enterococci (7\%). Gram-positive isolates accounted for more than 35\% of all isolates. Based on the susceptibility results to the predominant pathogens, the activity of the drugs tested could be categorized into three groups. Cefpirome and imipenem had the most potent in-vitro activity, followed by the third generation cephalosporins cefotaxime, ceftazidime and ceftriaxone, and then piperacillin. The large percentage of Gram-positive bacterial isolates in this patient population indicates the utility of antimicrobial agents that are equally effective against both Gram-positive and Gram-negative organisms.
This article was published in Scand J Infect Dis Suppl and referenced in Clinical & Medical Biochemistry

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

  • 2nd International Conference on Biochemistry
    Sep 21-22, 2017 Macau, Hong Kong
  • 7th International Conference on Predictive, Preventive and Personalized Medicine & Molecular Diagnostics
    Oct 23-25, 2017 Chicago, USA
  • International Conference on Biotech Pharmaceuticals
    October 23-25, 2017 Paris, France

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords