alexa Epidemiology of human cytomegalovirus (HCMV) in an urban region of Germany: what has changed?
Infectious Diseases

Infectious Diseases

Journal of Infectious Diseases & Therapy

Author(s): Lbeck PR, Doerr HW, Rabenau HF

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Abstract Since the dynamics of transmission of human cytomegalovirus (HCMV) have not been clarified yet, we assessed a possible change in HCMV seroprevalence in Frankfurt am Main, Germany during the past twenty years and tried to detect variables with an impact on epidemiology. Between 1/1/1988 and 10/15/2008, a total of 54443 serum samples were collected for routine diagnostics and analyzed using Enzygnost Anti HCMV-IgG enzyme immunoassay (Siemens/Dade Behring, Marburg, Germany). Two decades, 1/1/1988-12/31/1997 and 1/1/1998-10/15/2008, and several groups (type of health insurance, gender, age, HIV-status) were evaluated to assess changes in seroprevalence. Regarding both decades, the overall age-adjusted prevalence of HIV-negative patients dropped from 63.70\% (confidence interval (CI) 95\% 63.15-64.25) to 57.25\% (CI 95\% 56.57-57.93; P < 0.0001). Private health insurance (PHI) patients showed significant lower HCMV seroprevalences than members of obligatory health insurances (OHI) in both decades (1988-1997: PHI = 55.79\%, OHI = 64.27\%; P < 0.0001; 1998-1908: PHI = 47.02\%, OHI = 58.74\%; P < 0.0001). Furthermore, comparing the two decades, there was generally a gender-specific statistically significant decrease in HCMV seroprevalence for males (63.54-55.54\%) and females (63.83-58.73\%) as well as for members of PHI and OHI (PHI males: 57.59\% to 47.19\%, PHI females 54.10-46.80\%; OHI males: 64.00-57.06\%, OHI females 64.50-60.11\%). Also, while female HIV-positive patients showed significant difference in HCMV seroprevalence between the two decades (83.17 and 87.80\%, P = 0.023), there was no significant difference in male patients with HIV (88.76 and 87.32\% in the first and second decade, respectively (P = 0.196). The cumulative HCMV prevalence of all HIV-negative patients tested in the past 20 years demonstrates a biphasic, age-related rise of HCMV seroprevalence throughout all age-groups. The seroprevalence of HCMV has declined between 1988-1997 and 1998-2008 in Frankfurt am Main, Germany. The decline varied between different age-groups. HCMV prevalence correlates with the type of health insurance, gender, age, and HIV-status. This article was published in Med Microbiol Immunol and referenced in Journal of Infectious Diseases & Therapy

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