alexa Epidemiology of systemic vasculitis: a ten-year study in the United Kingdom.
Immunology

Immunology

Immunome Research

Author(s): Watts RA, Lane SE, Bentham G, Scott DG, Watts RA, Lane SE, Bentham G, Scott DG

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Abstract OBJECTIVE: To describe the epidemiology of the primary systemic vasculitides (PSV; Wegener's granulomatosis, Churg-Strauss syndrome, microscopic polyangiitis, polyarteritis nodosa) in a well-defined population over a 10-year period. METHODS: An inception cohort of patients from the Norwich Health Authority (NHA) who were >15 years of age and had PSV first diagnosed between January 1, 1988 and December 31, 1997 was collected. Incidence rates were adjusted for age and sex to the 1992 population. The prevalence of PSV in this cohort was estimated on December 31, 1997. Patients were classified according to the American College of Rheumatology 1990 vasculitis criteria and the Chapel Hill Consensus definitions. RESULTS: Eighty-two NHA residents fulfilled the inclusion criteria. There were 47 men and 35 women, with a mean age of 62.9 years (median 65.0 years). The overall annual incidence of PSV among NHA residents was 19.8/million (95\% confidence interval [95\% CI] 15.8-24.6). The point prevalence on December 31, 1997 was 144.5/million (95\% CI 110.4-185.3). PSV was more common in males (23.5/million; 95\% CI 17.3-31.3) than females (16.4/million; 95\% CI 11.4-22.8). The age- and sex-specific incidence showed a clear increase with age, with an overall peak in the 65-74 year age group (60.1/million). CONCLUSION: In our study population, the annual incidence of PSV is slowly increasing with time and the incidence is greatest in the elderly. This article was published in Arthritis Rheum and referenced in Immunome Research

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