alexa Epidermal growth factor receptor-containing exosomes induce tumor-specific regulatory T cells.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Stem Cell Research & Therapy

Author(s): Huang SH, Li Y, Zhang J, Rong J, Ye S

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Abstract The epidermal growth factor receptor (EGFR) has a close relation to lung cancer; its role in the pathogenesis of lung cancer is to be further elucidated. The results of this study indicate that about 80\% exosomes purified from the LC biopsies contained EGFR; only about 2\% exosomes contained EGFR in the samples from chronic lung inflammation. The purified exosomes induced tolerogenic DCs. Coculture of the tolerogenic DCs and Th0 cells generated the tumor antigen-specific regulatory T cells (Treg). The Tregs could suppress the tumor antigen specific CD8+ T cells. This article was published in Cancer Invest and referenced in Journal of Stem Cell Research & Therapy

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