alexa Epigenetic and microRNA-dependent control of cytochrome P450 expression: a gap between DNA and protein.
Clinical Research

Clinical Research

Journal of Clinical Trials

Author(s): Gomez A, IngelmanSundberg M

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Abstract Although pharmacogenetics has been instrumental in describing interindividual variations in drug metabolism, epigenetic factors offer another blanket of information that could give a more vivid picture and help in developing a more personalized therapy. The dynamic aspect of epigenetics could likewise provide more definite answers to the role of changing environmental factors in drug response: the bridge that connects the environment to the genome. In this review we discuss known epigenetic and microRNA-dependent regulation of the human drug-metabolizing cytochromes P450 to help explain the unknown factors of variable drug response. This article was published in Pharmacogenomics and referenced in Journal of Clinical Trials

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