alexa Epigenetic inactivation of the RASSF1A tumour suppressor gene in ependymoma.


Journal of Carcinogenesis & Mutagenesis

Author(s): Hamilton DW, Lusher ME, Lindsey JC, Ellison DW, Clifford SC

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Abstract To investigate the role of aberrant epigenetic events in ependymoma and identify critical genes in its pathogenesis, the methylation status of nine tumour suppressor genes (TSGs: p14(ARF), p15(INK4B), p16(INK4A), CASP8, MGMT, TIMP3, TP73, RB1 and RASSF1A) was assessed. Extensive hypermethylation across the RASSF1A CpG island was detected frequently in ependymomas of all clinical and pathological disease subtypes (86\% of cases, n=35), but not in non-neoplastic brain tissues (n=6). Less frequent methylation was observed for CASP8, MGMT and TP73 (5-20\%). The remaining TSGs showed no evidence of methylation. RASSF1A hypermethylation represents the most common gene-specific defect identified in ependymoma highlighting the importance of its further investigation in this disease. This article was published in Cancer Lett and referenced in Journal of Carcinogenesis & Mutagenesis

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