Author(s): Pirrotta V, Gross DS
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Abstract Transcriptional silencing in budding yeast and fruit fly is mediated by fundamentally unrelated proteins that assemble very different chromatin structures. Surprisingly, the repressive mechanisms evolved from these very different materials have similar features, including an epigenetic mode of inheritance and a block to transcription based on interference with the assembly or function of the promoter complex rather than with the binding of gene-specific activators.
This article was published in Mol Cell
and referenced in Journal of Stem Cell Research & Therapy