Author(s): Yokohira M, Matsuda Y, Suzuki S, Hosokawa K, Yamakawa K,
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Abstract A 2-y carcinogenicity study of Aloe, Aloe arborescens Miller var. natalensis Berger, a food additive, was conducted for assessment of toxicity and carcinogenic potential in the diet at doses of 4\% or 0.8\% in groups of male and female Wistar Hannover rats. Both sexes receiving 4\% showed diarrhea, with loss of body weight gain. The survival rate in the 4\% female group was significantly increased compared with control females after 2 y. Hematological and biochemical examination showed increase of RBC, Hb, and Alb in the 4\% males. The cause of these increases could conceivably have been dehydration through diarrhea. AST and Na were significantly decreased in the males receiving 4\%, and Cl was significantly decreased in both 4\% and 0.8\% males. A/G was significantly increased in the 4\% females, and Cl was significantly decreased (0.8\%) in the female group. Histopathologically, both sexes receiving 4\% showed severe sinus dilatation of ileocecal lymph nodes, and yellowish pigmentation of ileocecal lymph nodes and renal tubules. Adenomas or adenocarcinomas in the cecum, colon, and rectum were observed in 4\% males but not in the 0.8\% and control male groups. Similarly, in females, adenomas in the colon were also observed in the 4\% but not 0.8\% and control groups. In conclusion, Aloe, used as a food additive, exerted equivocal carcinogenic potential at 4\% high-dose level on colon in the 2-y carcinogenicity study in rats. Aloe is not carcinogenic at nontoxic-dose levels and that carcinogenic potential in at 4\% high-dose level on colon is probably due to irritation of the intestinal tract by diarrhea.
This article was published in J Food Sci
and referenced in Journal of Socialomics