alexa ERCC1 intron 1 was associated with breast cancer risk.
Genetics & Molecular Biology

Genetics & Molecular Biology

Hereditary Genetics: Current Research

Author(s): Mojgan H, Massoud H, Ahmad E

Abstract Share this page

Abstract INTRODUCTION: There are numerous studies addressing associations of polymorphisms in DNA repair genes and cancer risks because accurate and efficient DNA repair is crucial to genomic integrity and fidelity. ERCC1 is important in DNA nucleotide excision repair. MATERIAL AND METHODS: We genotyped constitutive variants of ERCC1 in approximately 300 adults with breast adenocarcinoma and 126 controls of Iranian women. In total, 426 Iranian sporadic breast cancer affected women compared to the control group were studied by PCR-RFLP for ERCC1 variant. RESULTS: The genotype ERCC1 TT has the highest frequency in both groups (36.6 in patients and 8.5 in controls). The genotype ERCC1 was the most important risk factor in our population [GG/AA odds ratio: 0.692, 95\% confidence interval (CI): 0.4-1.199, p = 0.188; GG/AG odds ratio: 3.333, 95\% CI: 1.917-5.795, p = 0.001; AA/AG odds ratio: 0.208, 95\% CI: 0.124-0.348, p = 0.342]. CONCLUSIONS: Our patients was associated with breast cancer risk.
This article was published in Arch Med Sci and referenced in Hereditary Genetics: Current Research

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords