alexa Escitalopram in the treatment of adolescent depression: a randomized placebo-controlled multisite trial.
Psychiatry

Psychiatry

Journal of Psychology & Psychotherapy

Author(s): Emslie GJ, Ventura D, Korotzer A, Tourkodimitris S

Abstract Share this page

Abstract OBJECTIVE: This article presents the results from a prospective, randomized, double-blind, placebo-controlled trial of escitalopram in adolescent patients with major depressive disorder. METHOD: Male and female adolescents (aged 12-17 years) with DSM-IV-defined major depressive disorder were randomly assigned to 8 weeks of double-blind treatment with escitalopram 10 to 20 mg/day (n = 155) or placebo (n = 157). The primary efficacy parameter was change from baseline to week 8 in Children's Depression Rating Scale-Revised (CDRS-R) score using the last observation carried forward approach. RESULTS: A total of 83\% patients (259/312) completed 8 weeks of double-blind treatment. Mean CDRS-R score at baseline was 57.6 for escitalopram and 56.0 for placebo. Significant improvement was seen in the escitalopram group relative to the placebo group at endpoint in CDRS-R score (-22.1 versus -18.8, p =.022; last observation carried forward). Adverse events occurring in at least 10\% of escitalopram patients were headache, menstrual cramps, insomnia, and nausea; only influenza-like symptoms occurred in at least 5\% of escitalopram patients and at least twice the incidence of placebo (7.1\% versus 3.2\%). Discontinuation rates due to adverse events were 2.6\% for escitalopram and 0.6\% for placebo. Serious adverse events were reported by 2.6\% and 1.3\% of escitalopram and placebo patients, respectively, and incidence of suicidality was similar for both groups. CONCLUSIONS: In this study, escitalopram was effective and well tolerated in the treatment of depressed adolescents. TRIAL REGISTRATION: ClinicalTrials.gov NCT00107120. This article was published in J Am Acad Child Adolesc Psychiatry and referenced in Journal of Psychology & Psychotherapy

Relevant Expert PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords