alexa Essential genes of a minimal bacterium.
Chemical Engineering

Chemical Engineering

Journal of Chemical Engineering & Process Technology

Author(s): Glass JI, AssadGarcia N, Alperovich N, Yooseph S, Lewis MR, , Glass JI, AssadGarcia N, Alperovich N, Yooseph S, Lewis MR, , Glass JI, AssadGarcia N, Alperovich N, Yooseph S, Lewis MR, , Glass JI, AssadGarcia N, Alperovich N, Yooseph S, Lewis MR,

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Abstract Mycoplasma genitalium has the smallest genome of any organism that can be grown in pure culture. It has a minimal metabolism and little genomic redundancy. Consequently, its genome is expected to be a close approximation to the minimal set of genes needed to sustain bacterial life. Using global transposon mutagenesis, we isolated and characterized gene disruption mutants for 100 different nonessential protein-coding genes. None of the 43 RNA-coding genes were disrupted. Herein, we identify 382 of the 482 M. genitalium protein-coding genes as essential, plus five sets of disrupted genes that encode proteins with potentially redundant essential functions, such as phosphate transport. Genes encoding proteins of unknown function constitute 28\% of the essential protein-coding genes set. Disruption of some genes accelerated M. genitalium growth.
This article was published in Proc Natl Acad Sci U S A and referenced in Journal of Chemical Engineering & Process Technology

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