alexa EST 2582 phase II trial of cisplatin in metastatic or recurrent thymoma.
Oncology

Oncology

Journal of Carcinogenesis & Mutagenesis

Author(s): Bonomi PD, Finkelstein D, Aisner S, Ettinger D

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Abstract In 1982 there were four reports of cisplatin-induced remissions of invasive thymoma. These observations led the Eastern Cooperative Oncology Group (ECOG) to conduct a Phase II trial of cisplatin (50 mg/m2 intravenously every 3 weeks). During a 4-year period 24 patients were entered on this trial; 3 were excluded because review of histologic material failed to confirm the presence of thymoma. The characteristics of the remaining 21 patients were as follows: median age, 51; males/females, 11/10; ECOG performance status, 0-1/2-3, 16/5; previous treatment with chemotherapy, 3; previous surgery, 20; previous radiation, 15; weight loss, < 5\%/ > or = 5\%: 17/4. One patient was eliminated from response analysis because of failure to return for follow-up tumor measurements. The following responses were observed in the remaining 20 patients. Partial remission, 2 (10\%); stable disease, 8 (40\%); and progression, 10 (50\%). The median survival was 76 weeks, and the 2-year survival rate was 39\%. Four patients experienced severe nausea and vomiting, but life-threatening and lethal toxicities were not observed. Cisplatin given at this dose was relatively ineffective in producing tumor regression in recurrent or metastatic thymoma.
This article was published in Am J Clin Oncol and referenced in Journal of Carcinogenesis & Mutagenesis

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