Author(s): Zhao Z, Nelson AR, Betsholtz C, Zlokovic BV, Zhao Z, Nelson AR, Betsholtz C, Zlokovic BV
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Abstract Structural and functional brain connectivity, synaptic activity, and information processing require highly coordinated signal transduction between different cell types within the neurovascular unit and intact blood-brain barrier (BBB) functions. Here, we examine the mechanisms regulating the formation and maintenance of the BBB and functions of BBB-associated cell types. Furthermore, we discuss the growing evidence associating BBB breakdown with the pathogenesis of inherited monogenic neurological disorders and complex multifactorial diseases, including Alzheimer's disease. Copyright © 2015 Elsevier Inc. All rights reserved.
This article was published in Cell
and referenced in Journal of Neuroinfectious Diseases