alexa Estimation of the current global burden of cryptococcal meningitis among persons living with HIV AIDS.
Infectious Diseases

Infectious Diseases

Journal of AIDS & Clinical Research

Author(s): Park BJ, Wannemuehler KA, Marston BJ, Govender N, Pappas PG, , Park BJ, Wannemuehler KA, Marston BJ, Govender N, Pappas PG,

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Abstract OBJECTIVE: Cryptococcal meningitis is one of the most important HIV-related opportunistic infections, especially in the developing world. In order to help develop global strategies and priorities for prevention and treatment, it is important to estimate the burden of cryptococcal meningitis. DESIGN: Global burden of disease estimation using published studies. METHODS: We used the median incidence rate of available studies in a geographic region to estimate the region-specific cryptococcal meningitis incidence; this was multiplied by the 2007 United Nations Programme on HIV/AIDS HIV population estimate for each region to estimate cryptococcal meningitis cases. To estimate deaths, we assumed a 9\% 3-month case-fatality rate among high-income regions, a 55\% rate among low-income and middle-income regions, and a 70\% rate in sub-Saharan Africa, based on studies published in these areas and expert opinion. RESULTS: Published incidence ranged from 0.04 to 12\% per year among persons with HIV. Sub-Saharan Africa had the highest yearly burden estimate (median incidence 3.2\%, 720 000 cases; range, 144 000-1.3 million). Median incidence was lowest in Western and Central Europe and Oceania (
  • DOI: 10.1097/QAD.0b013e328322ffac
  • This article was published in AIDS and referenced in Journal of AIDS & Clinical Research

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