alexa Estimations of intrinsic and extrinsic noise in models of nonlinear genetic networks.
Bioinformatics & Systems Biology

Bioinformatics & Systems Biology

Journal of Computer Science & Systems Biology

Author(s): Scott M, Ingalls B, Kaern M

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Abstract We discuss two methods that can be used to estimate the impact of internal and external variability on nonlinear systems, and demonstrate their utility by comparing two experimentally implemented oscillatory genetic networks with different designs. The methods allow for rapid estimations of intrinsic and extrinsic noise and should prove useful in the analysis of natural genetic networks and when constructing synthetic gene regulatory systems. This article was published in Chaos and referenced in Journal of Computer Science & Systems Biology

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