alexa Estrogen receptor expression in melasma: results from facial skin of affected patients.
Dermatology

Dermatology

Journal of Pigmentary Disorders

Author(s): Lieberman R, Moy L, Lieberman R, Moy L

Abstract Share this page

Abstract BACKGROUND AND OBJECTIVE: Melasma is a commonly acquired hypermelanosis of the skin due to various etiological factors, including pregnancy and oral contraceptives. Estrogen receptor expression in affected skin has not yet been investigated. The purpose of this study was to compare estrogen receptor expression in hyperpigmented and normal facial skin of patients with melasma. METHODS: Biopsies of 3 mm were taken from affected and unaffected forehead skin of 2 female patients with melasma. Frozen sections of the tissues were obtained and mouse monoclonal antibody against human estrogen receptors was tested at various dilutions to determine the optimum concentrations required for reproducible immunostaining with minimal background staining. Fluorescence was evaluated and compared qualitatively. RESULTS: The immunohistochemical staining of tissue from both patients reflected a qualitative increase in estrogen receptor expression in melasma-affected skin compared to unaffected skin. CONCLUSIONS: This study demonstrates the increased expression of estrogen receptors in melasma-affected skin and may establish the basis for exploring topical anti-estrogen therapies in melasma.
This article was published in J Drugs Dermatol and referenced in Journal of Pigmentary Disorders

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords