Author(s): Ferraz MB, Goldenberg J, Hilario MO, Bastos WA, Oliveira SK,
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Abstract OBJECTIVE: Although commonly used, the 1982 revised criteria for the classification of Systemic Lupus Erythematosus (SLE) have not been completely evaluated in pediatric patients. This study was aimed at evaluating the sensitivity and specificity of the 1982 revised criteria when applied to pediatric patients. METHODS: One hundred and three children with SLE and 101 children with other rheumatic diseases were selected from 5 rheumatology centers in Brazil. Diagnosis of SLE by the 1982 criteria were compared with our clinical diagnosis. The diagnosis of other diseases was made according to internationally accepted classification criteria or, when these were not available, according to the physician's own experienced judgement. RESULTS: The median number of criteria fulfilled by the patients with SLE and the controls were 6 and 1, respectively. The most common criteria observed in children with SLE were: abnormal antinuclear antibody titers (94\%), arthritis (83\%), immunologic disorder (83\%), hematologic disorder (70\%), malar rash (67\%), and photosensitivity (58\%). When the immunologic disorder was broken down into its constituent elements, antibodies to dsDNA and Sm were observed in 73.0\% (65/89) and 31.4\% (15/48), respectively. The sensitivity and specificity observed were 96\% and 100\%, respectively. CONCLUSION: The 1982 classification criteria can be successfully applied to children with SLE. These criteria may serve as a basis for multi-center collaborative studies on children with SLE.
This article was published in Clin Exp Rheumatol
and referenced in Clinics in Mother and Child Health