alexa Evaluation of the diuretic and analgesic activities of the rhizomes of Rumex abyssinicus Jacq in mice.
Chemistry

Chemistry

Natural Products Chemistry & Research

Author(s): Mekonnen T, Urga K, Engidawork E

Abstract Share this page

Abstract AIM OF THE STUDY: Rumex abyssinicus Jacq (Polygonaceae) has been used traditionally for treatment of hypertension, inflammatory and painful conditions in Ethiopia. The present study aimed to evaluate the diuretic and analgesic activities of extracts of Rumex abyssinicus at different doses in mice. MATERIALS AND METHODS: The effect on urine volume and urinary electrolyte (Na(+), K(+) and Cl(-)) was assessed for a period of 5h following oral administration of aqueous (500 mg/kg, 750 mg/kg or 1000 mg/kg) or 80\% methanolic (250 mg/kg, 500 mg/kg or 750 mg/kg) extract or furosemide (10mg/kg). Acetic acid-induced writhing and hot-plate tests were employed to study the analgesic effect of 80\% methanolic extracts (250 mg/kg, 500 mg/kg or 1000 mg/kg, P.O.) and compared with that of aspirin (100mg/kg, P.O.) or morphine (10mg/kg, sc). RESULTS: The extracts displayed dose-dependent diuretic and analgesic effects. The highest doses of both extracts markedly and significantly increased (P<0.001) urine volume and urinary electrolytes, qualitatively similar to that of furosemide. 1000 mg/kg of the extract reduced the number of writhing by 67.6\% (P<0.001) and conferred more than 70\% protection against thermally induced pain stimuli after 45 min of treatment comparable to that of aspirin and morphine, respectively. CONCLUSION: These findings collectively indicate that the extracts exhibited significant diuretic and analgesic activities, providing evidence, at least in part, for its folkloric use. Copyright 2009 Elsevier Ireland Ltd. All rights reserved. This article was published in J Ethnopharmacol and referenced in Natural Products Chemistry & Research

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords