alexa Evidence for endothelin-1 release from resistance vessels of rats in response to hypoxia.


Journal of Pulmonary & Respiratory Medicine

Author(s): Rakugi H, Tabuchi Y, Nakamaru M, Nagano M, Higashimori K,

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Abstract To elucidate further the contribution of endothelin into endothelium-dependent vasoconstriction evoked by hypoxia, we observed endothelin release during hypoxia. Endothelin was detectable in perfusate from mesenteric artery. Immunoreactive endothelin was confirmed as endothelin-1 by a reverse phase-HPLC. Endothelin release increased 4.1 +/- 1.3 to 12.4 +/- 2.0 pg/30 min without changing perfusion pressure. Thirty minutes of hypoxia stimulated endothelin release by 71 +/- 11\% (P less than 0.05) and was associated with an elevation of perfusion pressure. These results suggest that endothelin contributes to endothelium-dependent vasoconstriction by hypoxia in mesenteric artery and may play an important role in the local peripheral vascular tone.
This article was published in Biochem Biophys Res Commun and referenced in Journal of Pulmonary & Respiratory Medicine

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