alexa Evidence for the presence of a histaminergic neuron system in the rat brain: an immunohistochemical analysis.


Journal of Clinical & Experimental Neuroimmunology

Author(s): Watanabe T, Taguchi Y, Hayashi H, Tanaka J, Shiosaka S

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Histamine-containing cells in rats were identified by indirect immunofluorescent histochemistry using an antibody raised against histidine decarboxylase (HDC), the enzyme forming histamine, which was purified from fetal rat liver. HDC-like immunoreactive (HDCI) structures could be detected in the brain as well as in peritoneal mast cells and basal-granulated cells in deep crypts of the gastric mucosa of rats. Numerous HDCI neurons were found in the posterior hypothalamic area and HDCI nerve fibers with a varicose appearance of fluorescence were widely distributed in various regions of the brain.

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This article was published in Neurosci Lett and referenced in Journal of Clinical & Experimental Neuroimmunology

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